There was a failure executing the receive pipeline: Verify the schema for this document specification is deployed and is in the Global Assembly Cache

Problem

You might receive this error "There was a failure executing the receive pipeline: Verify the schema for this document specification is deployed and is in the Global Assembly Cache" in Biztalk 2010 while trying to submit a message to the receive location which is published with the WCF Service Publishing Wizard.

Solution

By default WCF service is running inside AppPool which is configured to use .Net Framework 2.0. Change WCF service AppPool to one which uses .Net Framework 4.0